Opposite Effects of the Acute Promyelocytic Leukemia PML-Retinoic Acid Receptor a (RARa) and PLZF-RARa Fusion Proteins on Retinoic Acid Signalling
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چکیده
MARTIN RUTHARDT, UGO TESTA, CLARA NERVI, PIER FRANCESCO FERRUCCI, FRANCESCO GRIGNANI, ELENA PUCCETTI, FAUSTO GRIGNANI, CESARE PESCHLE, AND PIER GIUSEPPE PELICCI* Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Istituto di Medicina Interna e Scienze Oncologiche, Policlinico Monteluce, Perugia University, 06100 Perugia, Department of Haematology and Oncology, Istituto Superlore di Sanità, 00161 Rome, and Dipartmento di Istologia ed Embriologia Medica, University of Rome “La Sapienza,” 00161 Rome, Italy, and Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541
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Ectopic repression of retinoic acid (RA) receptor target genes by PML/RARA and PLZF/RARA fusion proteins through aberrant recruitment of nuclear corepressor complexes drives cellular transformation and acute promyelocytic leukemia (APL) development. In the case of PML/RARA, this repression can be reversed through treatment with all-trans RA (ATRA), leading to leukemic remission. However, PLZF/R...
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تاریخ انتشار 1996